Reacción #83063

Ecuación de reacción

product

Ethanethioic acid S-[tetrahydro-5-[(phenylmethoxy)methyl]-3-thienyl]ester

trimethylsilyl iodide

→

product

Ethanethioic acid S-[tetrahydro-5-(iodomethyl)-3-thienyl]ester

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction is quenched with 100 ml of saturated sodium sulfite
2. 2
   Extracciónextracted with methylene chloride
3. 3
   Otrothe layers separated
4. 4
   OtroThe organic layer is dried
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated in vacuo
7. 7
   OtroThe residue is purified by

Procedimiento

A 0° C. mixture, under argon, of 0.44 g of product from Example 139 in 5 ml of dry chloroform is treated with 0.55 ml of trimethylsilyl iodide. The reaction is stirred, in the dark, for 2 hours. The reaction is quenched with 100 ml of saturated sodium sulfite, extracted with methylene chloride and the layers separated. The organic layer is dried, filtered and concentrated in vacuo. The residue is purified by. chromatography (silica gel: 0-100% methylene chloride/hexane) to give 0.31 g of the product.

Fuente