Reacción #82985

ord-0abcd3d5c3e549099ebe9ca4ca331704

Ecuación de reacción

Cl
hydrogen chloride
OC(CN1C2=NCCCN2c2ccccc21)c1ccc(Cl)cc1
base
OC(CN1C2=NCCCN2c2ccccc21)c1ccc(Cl)cc1
10-[2-Hydroxy-2-(4-chlorophenyl)ethyl]-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole
→
Cl.OC(CN1C2=NCCCN2c2ccccc21)c1ccc(Cl)cc1
10-[2-Hydroxy-2-(4-chlorophenyl)ethyl]-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole hydrochloride

Reactantes

Cl
hydrogen chloride
OC(CN1C2=NCCCN2c2ccccc21)c1ccc(Cl)cc1
base
OC(CN1C2=NCCCN2c2ccccc21)c1ccc(Cl)cc1
10-[2-Hydroxy-2-(4-chlorophenyl)ethyl]-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole

Reactivos

Ninguno

Disolventes

CC(C)O
isopropanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    FiltraciónSuction-filter
  2. 2
    Lavadowash with acetone

Procedimiento

Slowly add isopropanolic hydrogen chloride to an isopropanol solution of the base obtained in Step A. Wait for 30 minutes. Suction-filter, and wash with acetone.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05623073uspto-grants-1997_04