Reacción #8287

Ecuación de reacción

2-hydroxyaceto-phenone

pyridine

acetic anhydride

→

title compound

Acetic Acid 2-oxo-2-phenyl-ethyl ester

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe mixture is washed with water (200 mL) and brine (200 mL)
2. 2
   Secadothen dried over sodium sulfate
3. 3
   FiltraciónThe mixture is filtered
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.

Fuente