Reacción #82743

Ecuación de reacción

4-Fluoro-1-nitro-naphthalene

→

4-Fluoro-1-aminonaphthalene

Disolventes

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroplaced into a hydrogenating flask
2. 2
   OtroDuring the reaction
3. 3
   Otrothe pressure of the hydrogen dropped due to the consuming of the hydrogen, and it
4. 4
   FiltraciónThe resulting solution was filtered through a pad of celite
5. 5
   Lavadowashed with EtOAc (20 mL)
6. 6
   ConcentraciónThe clear filtrate was concentrated
7. 7
   Otrodried under vacuum

Procedimiento

4-Fluoro-1-nitro-naphthalene (1 g) was dissolved in EtOAc (20 mL) and placed into a hydrogenating flask containing Palladium on activated charcoal (10%, 0.3 g). The reaction mixture was hydrogenated at 50 psi for 5 hr. During the reaction, the pressure of the hydrogen dropped due to the consuming of the hydrogen, and it was brought back to 50 psi a few times. Finally, the reaction stopped when all the starting material was used. The resulting solution was filtered through a pad of celite and washed with EtOAc (20 mL). The clear filtrate was concentrated and dried under vacuum to yield 4-Fluoro-1-aminonaphthalene.

Fuente