Reacción #82742

Ecuación de reacción

cyanogen bromide

4-isopropylaniline

→

4-isopropylphenyl cyanamide

Rendimiento 84.0%

Disolventes

diethylether

diethylether

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe reaction mixture was kept stirring at room temperature for 18 h
3. 3
   OtroThen a solution with white precipitates
4. 4
   Otroformed
5. 5
   Otrothe precipitates were removed by filtration
6. 6
   LavadoThe etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine
7. 7
   Secadodried over MgSO4
8. 8
   Filtraciónfiltered
9. 9
   Concentraciónconcentrated
10. 10
    Otrodried under vacuum

Procedimiento

A solution of cyanogen bromide (1.59 g, 15 mmol) in diethylether (20) was added dropwise to a solution of 4-isopropylaniline (3.24 g) in diethylether (50 mL) at 4° C. with stirring. After the addition, the reaction mixture was kept stirring at room temperature for 18 h. Then a solution with white precipitates formed and the precipitates were removed by filtration. The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine, dried over MgSO4, filtered, concentrated, and dried under vacuum to yield 4-isopropylphenyl cyanamide (2.0 g, 84%).

Fuente