Reacción #827360

ord-763de7e6f62445e9838e5d6003b13cf7

Ecuación de reacción

Cc1ccc(N)cc1
Cc1ccc(N)cc1
FC(F)(F)c1ccc(Br)cc1
FC(F)(F)c1ccc(Br)cc1
→
Cc1ccc(Nc2ccc(C(F)(F)F)cc2)cc1
Cc1ccc(Nc2ccc(C(F)(F
Rendimiento 15.0%

Reactantes

Cc1ccc(N)cc1
Cc1ccc(N)cc1
FC(F)(F)c1ccc(Br)cc1
FC(F)(F)c1ccc(Br)cc1

Reactivos

CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c(C(C)C)c1
XPhos
CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C
P2Et
c1ccc(CN(Cc2ccccc2)c2ccon2)cc1
c1ccc(CN(Cc2ccccc2)c2ccon2)cc1

Disolventes

CS(C)=O
DMSO
CS(C)=O
DMSO
CS(C)=O
DMSO
CS(C)=O
DMSO
CS(C)=O
DMSO

Condiciones de reacción

Temperatura
60°CELSIUS

Tratamiento posterior

  1. 1
    workup.ADDITION

Procedimiento

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Fuente

DOI: 10.1126/science.aar5169Ahneman