Reacción #82457

Ecuación de reacción

Diethyl 5-acetyl-1,6-dihydro-6-oxo-2,3pyridinedicarboxylate

N,N-dimethylformamide dineopentyl acetal

→

diethyl 5-[3-(dimethylamino)acryloyl]-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate

Rendimiento 70.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe product is obtained as a precipitate
2. 2
   Filtraciónis filtered
3. 3
   Lavadowashed with hexane
4. 4
   Otroto yield 23.4 g, 70% yield
5. 5
   Otroof solid which is recrystallized from isopropanol
6. 6
   Otroto give a pure product, melting point 182°-183° C.

Procedimiento

Diethyl 5-acetyl-1,6-dihydro-6-oxo-2,3pyridinedicarboxylate, (25 g, 0.089 mol) and N,N-dimethylformamide dineopentyl acetal (50 mL, 98%, 40.62 g, 0.176 mol) are heated for 30 minutes at 80°-100° C. After cooling to room temperature, the product is obtained as a precipitate and is filtered and washed with hexane to yield 23.4 g, 70% yield, of solid which is recrystallized from isopropanol to give a pure product, melting point 182°-183° C.

Fuente