Reacción #8244

Ecuación de reacción

3-(4-(4-Hydroxymethylimidazol-1-yl)-3-fluorophenyl)-5(R)-(N-(t-butoxycarbonyl)isoxazol-3-ylaminomethyl)oxazolidin-2-one

trifluoroacetic acid

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title product

Rendimiento 66.9%

5(S)-Isoxazol-3-ylaminomethyl-3-(4(4-Hydroxymethylimidazol-1-yl)-3-fluorophenyl)oxazolidin-2-one

Rendimiento 66.9%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas evaporated
2. 2
   Otrothe residue repeatedly evaporated to dryness with dichloromethane (3×10 ml)
3. 3
   workup.DISSOLUTIONthe resulting gum dissolved in water (10 ml)
4. 4
   Filtraciónthe resulting precipitate filtered
5. 5
   Lavadowashed with water
6. 6
   Otrodried

Procedimiento

3-(4-(4-Hydroxymethylimidazol-1-yl)-3-fluorophenyl)-5(R)-(N-(t-butoxycarbonyl)isoxazol-3-ylaminomethyl)oxazolidin-2-one (360 mg, 0.76 mM) was dissolved in dichloromethane (10 ml) and treated with trifluoroacetic acid (10 ml). After stirring for 30 minutes solvent was evaporated, the residue repeatedly evaporated to dryness with dichloromethane (3×10 ml), and the resulting gum dissolved in water (10 ml). The solution was made basic with concentrated aqueous ammonia, and the resulting precipitate filtered, washed with water and dried to give title product (190 mg).

Fuente