Reacción #824275

Ecuación de reacción

4-Bromobenzyl bromide

2-Phenylpiperidine

acetonitrile

potassium carbonate

→

1-(4-Bromo-benzyl)-3-phenyl-piperidine

Rendimiento 54.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe solution was filtered through Celite
2. 2
   Concentraciónconcentrated in vacuo
3. 3
   Otroto afford a brown solid
4. 4
   OtroPurification
5. 5
   Otroto afford product

Procedimiento

5.632 g of 4-Bromobenzyl bromide and 2.422 g of 2-Phenylpiperidine (Array) in 50 mL of acetonitrile were stirred at room temperature and 6.229 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification was done by flash chromatography to afford product. Wt:0.908 g, 54% yield.

Fuente