Reacción #81712

Ecuación de reacción

water

methyl 2-(4'-hydroxymethylphenyl)benzoate

triethylamine

methanesulfonyl chloride

→

title compound

Rendimiento 100.0%

methyl 2-(4'-methanesulfonyloxymethylphenyl)benzoate

Rendimiento 100.0%

Disolventes

methylene chloride

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaUnder cooling with ice
2. 2
   OtroThe reaction liquid
3. 3
   Extracciónfollowed by the extraction with methylene chloride
4. 4
   LavadoAfter the organic phase was washed with water
5. 5
   Otrodried
6. 6
   Concentraciónit was subjected to vacuum concentration

Procedimiento

10.0 g (41 mmol) of methyl 2-(4'-hydroxymethylphenyl)benzoate and 8.4 g (83.0 mmol) of triethylamine were dissolved in methylene chloride (150 ml). Under cooling with ice, a solution of 5.7 g (50 mmol) of methanesulfonyl chloride in methylene chloride (25 ml) was dropwise added thereto, followed by further stirring for one hour. The reaction liquid was poured into water, followed by the extraction with methylene chloride. After the organic phase was washed with water and dried, it was subjected to vacuum concentration. 13.1 g of the title compound was obtained as a wax (yield 100%).

Fuente