Reacción #816394

Ecuación de reacción

phytantriol

acetone

→

2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofor 15 hr
2. 2
   OtroAfter the completion of the reaction
3. 3
   Otrothe acetone solvent was removed under reduced pressure
4. 4
   Extracciónthe resultant was extracted with chloroform solution
5. 5
   LavadoThe extract was washed with saturated sodium bicarbonate solution
6. 6
   Lavadowas again washed with saline

Procedimiento

One g of phytantriol (3.0 mmol, Sigma-Aldrich) was refluxed using deanstock apparatus for 15 hr in 25 ml of acetone solution with toluene sulfonic acid as catalyst. After the completion of the reaction, the acetone solvent was removed under reduced pressure and the resultant was extracted with chloroform solution. The extract was washed with saturated sodium bicarbonate solution and was again washed with saline to obtain 0.3 g of (2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol) of which 1- and 2-positions were protected.

Fuente