Reacción #8162

ord-41bda36bf6214c4a9b8efca6708532c2

Ecuación de reacción

Cl.NNC1CCCCC1
cyclohexyl hydrazine hydrochloride
CCOC(=O)C(C(C)=O)C(C)=O
2-acetyl-3-oxobutyric acid ethyl ester
c1ccncc1
pyridine
→
CCOC(=O)c1c(C)nn(C2CCCCC2)c1C
1-cyclohexyl-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester

Reactantes

—
product
Cl.NNC1CCCCC1
cyclohexyl hydrazine hydrochloride
CCOC(=O)C(C(C)=O)C(C)=O
2-acetyl-3-oxobutyric acid ethyl ester
c1ccncc1
pyridine

Reactivos

Ninguno

Disolventes

CCO
ethanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Similar to Example 1, equimolar amounts of cyclohexyl hydrazine hydrochloride and 2-acetyl-3-oxobutyric acid ethyl ester were combined in a solution of 50% pyridine in ethanol. Analysis confirmed synthesis of the named product (m.p. 66° C.–67° C.).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07087634B2uspto-grants-2006_08