Reacción #81612

Ecuación de reacción

Water

3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-fluorobenzoyl)benzenepropanoic acid

potassium carbonate

potassium carbonate

→

title compound

Rendimiento 85.9%

3- [2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl) benzenepropanoic acid

Rendimiento 85.9%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaunder reflux for 18 hours
3. 3
   Temperaturathe mixture was heated
4. 4
   Temperaturaunder reflux for a further 20 hours
5. 5
   Temperaturacooled
6. 6
   Otrothe solution was evaporated to about 10 ml
7. 7
   ExtracciónThe mixture was extracted several times with ethyl acetate
8. 8
   Lavadothe combined extracts were washed with water
9. 9
   Secadodried (MgSO4)
10. 10
    OtroEvaporation of the solvent

Procedimiento

A mixture of 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-fluorobenzoyl)benzenepropanoic acid (0.25 g) and potassium carbonate (0.212 g) in anhydrous methanol (5.0 ml) was heated under reflux for 18 hours. Additional potassium carbonate (0.212 g) was added and the mixture was heated under reflux for a further 20 hours and then cooled. Water (15 ml) was added and the solution was evaporated to about 10 ml and then acidified with 2N hydrochloric acid. The mixture was extracted several times with ethyl acetate and the combined extracts were washed with water and dried (MgSO4). Evaporation of the solvent gave the title compound as a glass (0.22 g). Found: C,60.25; H,4.92; N,2.51. C25H24ClNO6S requires C,59.81; H,4.82; N,2.79%.

Fuente