Reacción #81495

Ecuación de reacción

ethylene oxide

2-fluoro-6-methylpyridine

THF

LDA

→

2-fluoro-6-(3-hydroxypropyl)pyridine

Rendimiento 30.9%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato warm to room temperature
2. 2
   workup.STIRRINGwith stirring
3. 3
   Extracciónextracted with ether
4. 4
   Lavadothe organic layer was washed with water (2x) and brine
5. 5
   Secadodried over sodium sulfate
6. 6
   ConcentraciónThe organic solution was concentrated
7. 7
   Otrothe residue was purified by flash chromatography (chloroform/ethanol, 10:1)

Procedimiento

To a solution of 2-fluoro-6-methylpyridine (27 mmol) in 65 ml of freshly distilled THF was added via syringe 13.5 ml of 2M LDA, and the resulting mixture was stirred at -78° C. for 20 min. To the above cold solution was added 4 ml of 4M ethylene oxide and the mixture was allowed to warm to room temperature with stirring. The mixture was diluted with water, extracted with ether, and the organic layer was washed with water (2x) and brine, and dried over sodium sulfate. The organic solution was concentrated, and the residue was purified by flash chromatography (chloroform/ethanol, 10:1) to yield 1.3 g (30.9%) of 2-fluoro-6-(3-hydroxypropyl)pyridine, as a yellow oil.

Fuente