Reacción #8149

Ecuación de reacción

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

ethylamine

→

2-(ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene

Rendimiento 88.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter completion of the reaction
2. 2
   Concentraciónthe reaction mixture is concentrated in vacuo
3. 3
   workup.DISSOLUTIONThe residue is redissolved in EtOAc (10 mL)
4. 4
   Lavadowashed with saturated sodium bicarbonate solution, water, and brine
5. 5
   SecadoThe organic phase is then dried over sodium sulfate
6. 6
   Otrothe solvent is removed in vacuo

Procedimiento

A solution of 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene (2 mmol; preparation described in Example 5) in THF (5 mL) is treated with ethylamine (4 mmol) at rt. After completion of the reaction, the reaction mixture is concentrated in vacuo. The residue is redissolved in EtOAc (10 mL), washed with saturated sodium bicarbonate solution, water, and brine. The organic phase is then dried over sodium sulfate and the solvent is removed in vacuo to afford the product, 2-(ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene (520 mg) which was used for further transformation without further purification.

Fuente