Reacción #81306

ord-9f89e8b1b4b74688b1c61a07f00fa36b

Ecuación de reacción

CCOCC
diethyl ether
CCCc1nc(C#N)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1
2-propyl-1-tritylimidazole-4,5-dicarbonitrile
C[CH2][Mg][Br]
ethylmagnesium bromide
→
CCCc1nc(C(=O)CC)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1
title compound
CCCc1nc(C(=O)CC)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1
5-Cyano-4-Propionyl-2-propyl-1-tritylimidazole

Reactantes

CCOCC
diethyl ether
CCCc1nc(C#N)c(C#N)n1C(c1ccccc1)(c1ccccc1)c1ccccc1
2-propyl-1-tritylimidazole-4,5-dicarbonitrile
—
solution
C[CH2][Mg][Br]
ethylmagnesium bromide

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrothat described in Preparation 15

Procedimiento

Following a procedure similar to that described in Preparation 15, but using 8.05 g of 2-propyl-1-tritylimidazole-4,5-dicarbonitrile (prepared as described in Preparation 14) and 14 ml of a 3M solution of ethylmagnesium bromide in diethyl ether, 7.03 g of the title compound were obtained as crystals, melting at 96° C. (softening at 87° C.).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05616599uspto-grants-1997_04