Reacción #81297

Ecuación de reacción

sodium hydride

2-butylimidazole-4,5-dicarbonitrile

ethyl acetate

trityl chloride

→

title compound

Rendimiento 82.2%

2-Butyl-1-tritylimidazole-4,5-dicarbonitrile

Rendimiento 82.2%

Disolventes

N,N-dimethylformamide

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe reaction mixture was stirred at 50° C. for 6 hours
2. 2
   Extracciónthe product was extracted with ethyl acetate
3. 3
   SecadoThe extract was dried over anhydrous magnesium sulfate
4. 4
   Otrothe solvent was removed by distillation under reduced pressure
5. 5
   OtroThe resulting residue was purified by column chromatography through silica gel
6. 6
   workup.ADDITIONby volume mixture of ethyl acetate and hexane as the eluent

Procedimiento

1.25 g of sodium hydride (as a 55% w/w dispersion in mineral oil) were added, whilst ice-cooling, to a solution of 5 g of 2-butylimidazole-4,5-dicarbonitrile (prepared as described in Preparation 1) in 50 ml of N,N-dimethylformamide, and the resulting mixture was stirred for 15 minutes. 10 g of trityl chloride were then added, and the reaction mixture was stirred at 50° C. for 6 hours. At the end of this time, it was mixed with ethyl acetate and water, and the product was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 1:5 by volume mixture of ethyl acetate and hexane as the eluent, to give 9.83 g of the title compound as a syrup, which solidified on being allowed to stand. The solid melted at 144°-147° C. (with decomposition and coloration at 94°-98° C.).

Fuente