Reacción #811612

Ecuación de reacción

4-methyl-3-nitro-phenyl boronic acid

→

3-amino-4-methyl phenyl boronic acid

Rendimiento 91.0%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat 23° C
2. 2
   FiltraciónAfter 22 h the reaction mixture was filtered through celite and
3. 3
   Concentraciónconcentrated

Procedimiento

A mixture of 4-methyl-3-nitro-phenyl boronic acid (3.34 g, 18.45 mmol) and 10% Pd/C (334 mg) in MeOH (30 ml) was hydrogenated (1 atm.) at 23° C. After 22 h the reaction mixture was filtered through celite and concentrated to give 3-amino-4-methyl phenyl boronic acid (2.53 g, 91%). 1H N (300 MHz, DMSO-d6) δ 7.21 (s, 1H), 7.08 (d, 1H, J=7.5 Hz), 6.92 (d, 1H, J=7.46 Hz), 4.81 (bs, 2H), 2.09 (s, 3H). MS (ESI) [M+H]/z Calc'd 152. found 152.

Fuente