Reacción #81144

Ecuación de reacción

(1RS, 2RS)-3-(4-biphenylyl)-2-(4-chlorophenyl)-1-methylpropylamine

N-{(1RS, 2RS)-2-(4-chlorophenyl)-3-(2-fluoro-4-biphenylyl)-1-methylpropyl}-2naphthylmethylamine

N-{(1RS, 2RS)-3-(3-biphenylyl)-2-(4-chlorophenyl)-1-methylpropyl}-2naphthylmethylamine

N-{(1RS, 2RS)-3-(4'-chloro-4-biphenylyl)-2-(4-chlorophenyl)-1-methylpropyl}-2naphthylmethylamine

N-{(1RS, 2RS)-2-(4-chlorophenyl)-3-(6-fluoro-3-biphenylyl)-1-methylpropyl}-2naphthylmethylamine

N-[(1RS, 2RS)-2-(4-chlorophenyl)-1-methyl-3-{3-(2-naphthyl)phenyl}propyl]-2-naphthylmethylamine

N-{(1RS, 2RS)-3-(4-biphenylyl)-1-methyl-2-(2-naphthyl)propyl}-2-naphthylmethylamine

N-{(1RS, 2RS)-3-(4-biphenylyl)-2-(3,4-dichlorophenyl)-1-methylpropyl}-2-naphthylmethylamine

→

N-{(1RS, 2RS)-3-(4-biphenylyl)-2-(4- chlorophenyl)-1-methylpropyl}-2-naphthylmethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroused in the above reaction

Procedimiento

The following compounds were prepared in the same manner as in Reference Example 2 except that (1RS, 2RS)-3-(4-biphenylyl)-2-(4-chlorophenyl)-1-methylpropylamine used in the above reaction was changed to the corresponding amine compounds: N-{(1RS, 2RS)-3-(3-biphenylyl)-2-(4-chlorophenyl)-1-methylpropyl}-2naphthylmethylamine, N-{(1RS, 2RS)-3-(4'-chloro-4-biphenylyl)-2-(4-chlorophenyl)-1-methylpropyl}-2naphthylmethylamine, N-{(1RS, 2RS)-2-(4-chlorophenyl)-3-(2-fluoro-4-biphenylyl)-1-methylpropyl}-2naphthylmethylamine, N-{(1RS, 2RS)-2-(4-chlorophenyl)-3-(6-fluoro-3-biphenylyl)-1-methylpropyl}-2naphthylmethylamine, N-[(1RS, 2RS)-2-(4-chlorophenyl)-1-methyl-3-{3-(2-naphthyl)phenyl}propyl]-2-naphthylmethylamine, N-{(1RS, 2RS)-3-(4-biphenylyl)-2-(3,4-dichlorophenyl)-1-methylpropyl}-2-naphthylmethylamine and N-{(1RS, 2RS)-3-(4-biphenylyl)-1-methyl-2-(2-naphthyl)propyl}-2-naphthylmethylamine.

Fuente