Reacción #80992

Ecuación de reacción

N,N-diethylthiourea

ethyl bromopyruvate

MgSO4

→

desired compound

Rendimiento 140.4%

Ethyl 2-(N,N-Diethylamino)thiazole-4-carboxylate

Rendimiento 140.4%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturaat reflux for 1 h
3. 3
   FiltraciónThe resulting mixture was filtered
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

A solution of 0.972 g (7.36 mmol) of N,N-diethylthiourea and 1.02 ml (8.1 mmol) of ethyl bromopyruvate in 25 ml of acetone was treated with excess solid MgSO4 and heated at reflux for 1 h. The resulting mixture was filtered, and concentrated in vacuo. Silica gel chromatography using CHCl3 provided 2.36 g (38%) of the desired compound as an oil. Mass spectrum: (M+H)+ =229.

Fuente