Reacción #809073

Ecuación de reacción

3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

2,4-dimethoxy-1-benzenecarbonyl chloride

2,4-dimethoxy-1-benzenecarbonyl isothiocyanate

→

2,4-Dimethoxy-1-benzenecarbonyl isothiocyanate

title compound

Rendimiento 63.0%

N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,4-dimethoxybenzoyl)thiourea

Rendimiento 63.0%

Disolventes

toluene

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction solution was concentrated
2. 2
   Otrothe residue was purified by chromatography on silica gel

Procedimiento

2,4-Dimethoxy-1-benzenecarbonyl isothiocyanate was prepared using commercially available 2,4-dimethoxy-1-benzenecarbonyl chloride (80 mg) as a starting compound according to the description of the literature. 3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline (50 mg) was dissolved in toluene (5 ml) and ethanol (1 ml) to prepare a solution. A solution of 2,4-dimethoxy-1-benzenecarbonyl isothiocyanate in ethanol (1 ml) was then added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (53 mg, yield 63%).

Fuente