Reacción #80904

Ecuación de reacción

2-amino-5-bromo-6-chlorobenzonitrile

3,5-dichlorophenylboronic acid

sodium carbonate

→

2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile

Rendimiento 63.9%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThis compound was prepared in a manner analogous to that of Step D of Example 1
2. 2
   OtroThe solid product was recrystallized from toluene

Procedimiento

This compound was prepared in a manner analogous to that of Step D of Example 1, using 2.3 grams (0.010 mole) of 2-amino-5-bromo-6-chlorobenzonitrile (prepared as in Step A of Example 2), 2.9 grams (0.015 mole) of 3,5-dichlorophenylboronic acid, 0.1 gram (catalyst) of tetrakis(triphenylphosphine)palladium(0), and 30 mL of aqueous 2M sodium carbonate in 75 mL of toluene. The solid product was recrystallized from toluene, yielding 1.9 grams of 2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile. The NMR spectrum was consistent with the proposed structure.

Fuente