Reacción #805676

Ecuación de reacción

compound ( 69 )

4′-bromo-2′-fluoro-4-propyl-2,3,4,5-tetrahydro-1,1′-biphenyl

toluene

→

4-bromo-2-fluoro-1-(4-propylcyclohexyl)benzene

Rendimiento 78.1%

Disolventes

IPA

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction mixture was filtered
2. 2
   workup.DISTILLATIONa solvent in a filtrate was distilled off by an evaporator
3. 3
   workup.DISTILLATIONa low-boiling-point material was distilled off by distillation

Procedimiento

A mixture of compound (69) (39.2 g, 131.9 mmol) and 5%-palladium on carbon (0.5% sulfur, 50% water-containing article) (1.18 g, 3 wt %) was agitated for 18 hours under a hydrogen atmosphere in a toluene (200 mL)-IPA (100 mL) solvent. The reaction mixture was filtered and a solvent in a filtrate was distilled off by an evaporator. The residue was passed through silica gel column chromatography and then a low-boiling-point material was distilled off by distillation, and thus 4-bromo-2-fluoro-1-(4-propylcyclohexyl)benzene (70) (30.8 g, yield 78.1%) was obtained.

Fuente