Reacción #80427

Ecuación de reacción

2-((3-Methyl-4-(2-benzylaminoethylthio)pyridin-2-yl)methylthio)-1H-benzimidazole

methyl chloroacetate

potassium carbonate

→

2-((3-methyl-4-(2-(N-benzyl-N-methoxycarbonylmethylamino)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the completion of the reaction
2. 2
   workup.DISTILLATIONthe dimethylformamide was distilled away
3. 3
   Extracciónthe residue was extracted with ethyl acetate
4. 4
   SecadoThe ethyl acetate layer was dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled away
6. 6
   Otroto give an oily product
7. 7
   OtroThe oily product was purified by column chromatography

Procedimiento

2-((3-Methyl-4-(2-benzylaminoethylthio)pyridin-2-yl)methylthio)-1H-benzimidazole (2 g) was dissolved in dimethylformamide and reacted with methyl chloroacetate (0.45 ml) in the presence of potassium carbonate (0.71 g) at 50°-60° C. After the completion of the reaction, the dimethylformamide was distilled away and the residue was extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate and the solvent was distilled away to give an oily product. The oily product was purified by column chromatography to give 2-((3-methyl-4-(2-(N-benzyl-N-methoxycarbonylmethylamino)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole.

Fuente