Reacción #80271

Ecuación de reacción

water

4-formyl-5-hydroxy-3-methylbenzothiophene

4,6-dimethoxy-2-methylsulfonylpyrimidine

potassium carbonate

→

desired compound

Rendimiento 86.0%

5-(4,6-dimethoxypyrimidin-2-yl)oxy-4-formyl-3-methylbenzothiophene

Rendimiento 86.0%

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Otrowas returned to room temperature
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoThe organic layer was washed with water
5. 5
   Secadodried over anhydrous sodium sulfate
6. 6
   ConcentraciónThen, it was concentrated under reduced pressure
7. 7
   Otrothe oily substance thereby obtained
8. 8
   Otrowas purified by silica gel column chromatography (n-hexane/ethyl acetate=10/1)

Procedimiento

A mixture comprising 2.1 g of 4-formyl-5-hydroxy-3-methylbenzothiophene, 2.4 g of 4,6-dimethoxy-2-methylsulfonylpyrimidine and 1.8 g of potassium carbonate in 30 ml of N,N-dimethylformamide, was heated and stirred at 70° C. for 3 hours. The mixture was returned to room temperature, then poured into water and extracted with ethyl acetate. The organic layer was washed with water and then dried over anhydrous sodium sulfate. Then, it was concentrated under reduced pressure, and the oily substance thereby obtained was purified by silica gel column chromatography (n-hexane/ethyl acetate=10/1) to obtain 3.1 g (yield: 86%) of the desired compound.

Fuente