Reacción #801957

Ecuación de reacción

sodium hydroxide

2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4(3H)-one

2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4 (3H)-one

phosphorus oxychloride

→

title compound

4-chloro-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate
2. 2
   LavadoThe organic layer was washed with saturated brine
3. 3
   Secadodried over anhydrous sodium sulfate
4. 4
   Otrothe solvent was evaporated

Procedimiento

To a solution of 2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4(3H)-one (3.4 g) obtained in Step B in acetonitrile (35 mL) was added dropwise phosphorus oxychloride (3.2 mL), and the mixture was stirred at 80° C. for 2 hr. The reaction mixture was neutralized with 8M aqueous sodium hydroxide solution, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated to give the title compound (3.3 g).

Fuente