Reacción #80133

Ecuación de reacción

hydrochloric acid

2-amino-4-methoxybenzothiazole

pyridine

methyl chloroformate

→

(4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester

Rendimiento 99.3%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe organic phase was separated
2. 2
   Lavadowashed with brine
3. 3
   Secadodried over sodium sulfate
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

To a stirred solution of 23.6 g (131 mmol) 2-amino-4-methoxybenzothiazole and 12.6 ml (157 mmol) pyridine in 230 ml dichloromethane at 0° C. was added dropwise 10.6 ml (137 mmol) methyl chloroformate and stirring continued for 1 hour. The mixture was then poured onto 1 M hydrochloric acid and the organic phase was separated, washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford 31.0 g (99%) (4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester as a white solid. ES-MS m/e (%): 239 (M+H+, 100).

Fuente