Reacción #80036

Ecuación de reacción

H2O

4-bromo-3-tert-butylphenol

Intermediate 104

4-bromo-3-tert-butylphenol

imidazole

chloro-triisopropylsilane

→

title compound

(4-Bromo-3-tert-butyl-phenoxy)-triisopropyl-silane

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with EtOAc
2. 2
   LavadoThe combined organic layers were washed with H2O and saturated aqueous NaCl
3. 3
   Secadobefore being dried (MgSO4)
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

To a solution of 4-bromo-3-tert-butylphenol (Intermediate 104, 1.17 g, 5.10 mmols) and imidazole (520.0 mg, 7.65 mmols) in 10 mL DMF was added chloro-triisopropylsilane (1.18 g, 6.10 mmols). After stirring overnight at room temperature the solution was diluted wirth H2O and extracted with EtOAc. The combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound, 1.80 g (92%), was isolated by column chromatography (0-1.5% EtOAc-hexanes) as a colorless oil.

Fuente