Reacción #799649

Ecuación de reacción

LiAlH4

2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione

→

title compound

Rendimiento 25.4%

2-benzyloctahydro-1H-pyrrolo[3,4-c]pyridine

Rendimiento 25.4%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was refluxed for 6 h under N2
2. 2
   Otroquenched with ice-water
3. 3
   Filtraciónfiltered
4. 4
   ConcentraciónThe filtrate was concentrated in vacuo

Procedimiento

To a solution of LiAlH4 (1.00 g) in THF was added slowly 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione (2.00 g) at 0° C. The reaction mixture was refluxed for 6 h under N2, and cooled to rt, quenched with ice-water and filtered. The filtrate was concentrated in vacuo to give the title compound as yellow oil (0.45 g, 25%). The crude product was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 217.2 (M+1).

Fuente