Reacción #799648

Ecuación de reacción

2-benzyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione

water

→

title compound

Rendimiento 61.3%

2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione

Rendimiento 61.3%

Disolventes

glycol monomethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to rt
2. 2
   Extracciónextracted with CH2Cl2 (70 mL×3)
3. 3
   SecadoThe combined organic phases were dried over anhydrous Na2SO4
4. 4
   Filtraciónfiltered
5. 5
   ConcentraciónThe filtrate was concentrated in vacuo

Procedimiento

To a solution of 2-benzyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione (3.50 g) in glycol monomethyl ether was added a catalytic amount of 10% Pd/C. The suspension was heated to 35° C. and stirred for 6 h under H2, then cooled to rt, poured into 100 mL of water and extracted with CH2Cl2 (70 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo to give the title compound as yellow oil (2.20 g, 60%). The crude product was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 245.2 (M+1).

Fuente