Reacción #7984

Ecuación de reacción

2-butyl-6-fluoro-5-methoxy-1-indanone

pyridine hydrochloride

→

2-butyl-6-fluoro-5-hydroxy-1-indanone

Rendimiento 95.1%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to room temperature
2. 2
   Otrothe mixture was partitioned between EtOAc (100 mL) and water (75 mL)
3. 3
   workup.ADDITIONcontaining brine (25 mL)
4. 4
   LavadoThe organic phase was washed with brine (50 mL)
5. 5
   Secadodried over MgSO4
6. 6
   Filtraciónfiltered
7. 7
   Otroevaporated under vacuum

Procedimiento

A mixture of 2-butyl-6-fluoro-5-methoxy-1-indanone (2.0 g) and pyridine hydrochloride (15.0 g) was heated in an oil bath at 200° C. for 75 minutes. After cooling to room temperature, the mixture was partitioned between EtOAc (100 mL) and water (75 mL) containing brine (25 mL). The organic phase was washed with brine (50 mL), dried over MgSO4, filtered, and evaporated under vacuum to provide 2-butyl-6-fluoro-5-hydroxy-1-indanone (1.79 g) as a solid.

Fuente