Reacción #79770

Ecuación de reacción

4-Amino-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-ylphenol

2-fluoro-6-(3-imidazol-1-yl)propylamino benzonitrile

potassium carbonate

→

2-[4-(4-amino-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenoxy]-6-(3-imidazol-1-yl)propylaminobenzonitrile

Disolventes

dimethylformamide

Condiciones de reacción

Procedimiento

4-[4-Amino-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-ylphenol (0.49 g), 2-fluoro-6-(3-imidazol-1-yl)propylamino benzonitrile, potassium carbonate (0.45 g) and dimethylformamide were reacted in a similar manner to Example 17 to give 2-[4-(4-amino-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenoxy]-6-(3-imidazol-1-yl)propylaminobenzonitrile, m.p.110° C. (glassy foam).

Fuente