Reacción #79513

Ecuación de reacción

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

4-methyl-3-pyrrolecarboxylic acid

β-alanine ethyl ester hydrochloride

triethylamine

→

title compound

Rendimiento 43.1%

Ethyl 3-(4-methyl-3-pyrrolecarboxamido)propionate

Rendimiento 43.1%

Disolventes

methylene chloride

Condiciones de reacción

Procedimiento

Using 7.63 g (60 mmol) of 4-methyl-3-pyrrolecarboxylic acid, 15.4 g (100 mmol) of β-alanine ethyl ester hydrochloride, 14 ml (100 mmol) of triethylamine, 17.3 g (90 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 100 ml of methylene chloride, 5.80 g of the title compound were obtained in a similar manner as in Example 2 (yield: 26%).

Fuente