Reacción #79512

Ecuación de reacción

1-ethyl-3-pyrrolecarboxylic acid

β-alanine ethyl ester hydrochloride

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

triethylamine

→

Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added dropwise under ice cooling
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 2.5 hours

Procedimiento

Into a suspension of 3.33 g (23.9 mmol) of 1-ethyl-3-pyrrolecarboxylic acid, 4.41 g (28.7 mmol) of β-alanine ethyl ester hydrochloride and 5.50 g (28.7 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride in 40 ml of methylene chloride, 4.0 ml (28.7 mmol) of triethylamine were added dropwise under ice cooling and stirring. The reaction mixture was stirred at room temperature for 2.5 hours.

Fuente