Reacción #79507

ord-e4500b562298474d8b083b3d1e1b340c

Ecuación de reacción

CNC(=O)c1sc(C)c(C)c1C(=O)c1ccccc1
16a
CNC(=O)c1sc(C)c(C)c1C(=O)c1ccccc1
3-benzoyl-4,5-dimethylthiophene-2-carboxylic acid methylamide
[K+].[OH-]
KOH
→
Cc1sc(C(=O)O)c(C(=O)c2ccccc2)c1C
3-benzoyl-4,5-dimethylthiophene-2-carboxylic acid

Reactantes

CNC(=O)c1sc(C)c(C)c1C(=O)c1ccccc1
16a
CNC(=O)c1sc(C)c(C)c1C(=O)c1ccccc1
3-benzoyl-4,5-dimethylthiophene-2-carboxylic acid methylamide
[K+].[OH-]
KOH

Reactivos

Ninguno

Disolventes

CO.O
methanol water

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Temperaturaat reflux for 12 hours
  2. 2
    Extracciónextracted with ethyl acetate
  3. 3
    OtroThe solid after evaporation
  4. 4
    Otrowas crystallized from ethanol

Procedimiento

A solution of 16a (0.281 g, 1.03 mmole) in methanol-water 1:1 containing 10% KOH was heated at reflux for 12 hours, neutralized and extracted with ethyl acetate. The solid after evaporation was crystallized from ethanol. Yield 0.19 g, 71%.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06713638B2uspto-grants-2004_03