Reacción #792628

Ecuación de reacción

CDI

Z-Glu-OBn

2-amino-4-chlorophenol-6-sulfonic acid

THF

→

title compound

Rendimiento 40.0%

N5-(2-hydroxy-3-sulfophenyl)-L-glutamine

Rendimiento 40.0%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGstirred overnight at room temperature
2. 2
   OtroAfter removing
3. 3
   Otroa solvent, purification
4. 4
   workup.DISSOLUTIONThe obtained intermediate was dissolved in a mixed solvent of methanol and water
5. 5
   workup.ADDITIONPd/C in catalyst quantity was added
6. 6
   workup.STIRRINGstirred under hydrogen atmosphere overnight at room temperature
7. 7
   FiltraciónAfter filtering out the catalyst
8. 8
   Otroremoving
9. 9
   Otroa solvent, purification

Procedimiento

Z-Glu-OBn (371 mg, 1 mmol) was dissolved in methylene chloride (1 mL), and CDI (180 mg, 1.1 mmol) was added thereto and stirred at room temperature for 30 minutes. Then, 2-amino-4-chlorophenol-6-sulfonic acid (223 mg, 1 mmol) and THF (1 mL) were added thereto and stirred overnight at room temperature. After removing a solvent, purification was conducted in accordance with the purification process A. The obtained intermediate was dissolved in a mixed solvent of methanol and water. Pd/C in catalyst quantity was added thereto and stirred under hydrogen atmosphere overnight at room temperature. After filtering out the catalyst and removing a solvent, purification was conducted in accordance with the purification process A to obtain a title compound.

Fuente