Reacción #792181

Ecuación de reacción

Potassium hydroxide

ethyl 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate

product

ethyl 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate

→

product

Rendimiento 93.0%

1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

Rendimiento 93.0%

Disolventes

water

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvent was removed under reduced pressure
2. 2
   workup.DISSOLUTIONthe mixture was dissolved in water (40 mL)
3. 3
   LavadoThe solution was washed with ethyl acetate (20 mL)
4. 4
   Extracciónwas extracted with ethyl acetate (3×20 mL)
5. 5
   OtroThe combined extracts were dried
6. 6
   Otroevaporated
7. 7
   Otroto give

Procedimiento

Potassium hydroxide (0.5 g, 85%, 2.28 mmol) in water (1 mL) was added to ethyl 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate (i.e. the product of Step D) (0.66 g, 2.07 mmol) in ethanol (3 mL). After about 30 minutes, the solvent was removed under reduced pressure, and the mixture was dissolved in water (40 mL). The solution was washed with ethyl acetate (20 mL). The aqueous layer was acidified with concentrated hydrochloric acid and was extracted with ethyl acetate (3×20 mL). The combined extracts were dried and evaporated to give the product as a solid (0.53 g, 93% yield), m.p. 178-179° C. (after crystallization from hexanes-ethyl acetate).

Fuente