Reacción #792153

Ecuación de reacción

2-chloro-3-trifluoromethylpyridine

3-trifluoromethylpyrazole

potassium carbonate

→

title compound

Rendimiento 62.2%

3-Trifluoromethyl-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine

Rendimiento 62.2%

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe cooled reaction mixture
2. 2
   ExtracciónThe mixture was extracted twice with ether (100 mL)
3. 3
   Lavadothe combined ether extracts were washed twice with water (100 mL)
4. 4
   SecadoThe organic layer was dried with magnesium sulfate
5. 5
   Concentraciónconcentrated to an oil

Procedimiento

A mixture of 2-chloro-3-trifluoromethylpyridine (3.62 g., 21 mmol), 3-trifluoromethylpyrazole (2.7 g., 20 mmol), and potassium carbonate (6.0 g, 43 mmol) were heated at 100° C. for 18 h. The cooled reaction mixture was added to ice/water (100 mL). The mixture was extracted twice with ether (100 mL) and the combined ether extracts were washed twice with water (100 mL). The organic layer was dried with magnesium sulfate and concentrated to an oil. Chromatography on silica gel with hexanes:ethyl acetate 8:1 to 4:1 as eluent gave the title compound (3.5 g) as an oil.

Fuente