Reacción #792145

Ecuación de reacción

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

→

final compound

Rendimiento 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

Rendimiento 84.7%

Disolventes

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas conducted at atmospheric pressure room temperature until the starting material
2. 2
   FiltraciónThe catalyst was filtered
3. 3
   Otrothe crude was purified by chromatography on silica gel (25% EtOAc/hexane)

Procedimiento

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

Fuente