Reacción #791678

Ecuación de reacción

methyl acetoacetate

methoxy acetic acid

aminoguanidine bicarbonate

nitric acid

→

title compound

7-hydroxy-2-methoxymethyl-5-methyl-s-triazolo[1,5-a]pyrimidine

Disolventes

acetic acid

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 24 hours
2. 2
   Otrocondensed
3. 3
   workup.STIRRINGthe mixture was stirred in a bath of 100 to 120° C
4. 4
   Temperaturathe mixture was cooled
5. 5
   Filtracióncrystals were collected by filtration
6. 6
   Lavadowashed with isopropanol
7. 7
   Otrodried

Procedimiento

A mixture of 90 g of methoxy acetic acid, 68 g of aminoguanidine bicarbonate, 40 ml of water and 0.5 ml of conc. nitric acid was stirred under reflux for 24 hours, and then condensed. To the resulting residue were added 250 ml of methyl acetoacetate and 5 ml of acetic acid and the mixture was stirred in a bath of 100 to 120° C. After 4 hours, the mixture was cooled by allowing to stand and crystals were collected by filtration, washed with isopropanol and dried to obtain 82 g of the title compound.

Fuente