Reacción #791579

Ecuación de reacción

hydrochloric acid

3-(4-methoxyphenyl)propionic acid

lithium aluminum hydride

water

→

3-(4-methoxyphenyl)propanol

Disolventes

ether

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGAfter stirring at room temperature for 30 minutes
2. 2
   Temperaturathe mixture was refluxed for 1 hours
3. 3
   TemperaturaAfter cooling
4. 4
   Extracciónextracted with ether
5. 5
   LavadoThe organic layer was washed with saturated aqueous solution of sodium chloride
6. 6
   Concentraciónconcentrated under reduced pressure

Procedimiento

A solution of the 3-(4-methoxyphenyl)propionic acid in 100 ml of anhydrous ether was added dropwise to a suspension of 1.10 g of lithium aluminum hydride in 50 ml of anhydrous ether with stirring at room temperature over 20 minutes. After stirring at room temperature for 30 minutes, the mixture was refluxed for 1 hours. After cooling, water was added with ice cooling, and the mixture was made acidic by further addition of 10% hydrochloric acid and then extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, driven over anhydrous magnesium sulfate and concentrated under reduced pressure to give 5.06 g of 3-(4-methoxyphenyl)propanol.

Fuente