Reacción #790597

Ecuación de reacción

3-aminoquinuclidine dihydrochloride

2-furoylurea

succinate

diisopropylethylamine

→

N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-furancarboxamide

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe above compound was prepared

Procedimiento

The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride (1.0 g, 5 mmol), 2-furoylurea (0.77 g, 5 mmol), and diisopropylethylamine (1.3 g, 10 mmol) in pyridine (20 ml). The product (0.58 g) was converted to the 1:1 succinate mp 156°-159° C.

Fuente