Reacción #7898

Ecuación de reacción

(R)-2-hydroxy-3-phenylpropionic acid

sulfuric acid

methanol

→

solid

Rendimiento 85.0%

(R)-2-Hydroxy-3-phenylpropionic acid methyl ester

Rendimiento 85.0%

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawarmed to room temperature for 24 h
2. 2
   ConcentraciónConcentration in vacuo
3. 3
   Otrogave a residue which
4. 4
   Lavadowashed with water, saturated sodium bicarbonate and brine
5. 5
   OtroThe organic layer was separated
6. 6
   Secadodried with sodium sulfate
7. 7
   Filtraciónfiltered
8. 8
   Concentraciónconcentrated in vacuo

Procedimiento

To a solution of (R)-2-hydroxy-3-phenylpropionic acid (1.5 g, 12.9 mol) in methanol (18 mL) at 0° C. was added concentrated sulfuric acid (0.2 mL). The reaction mixture was stirred at 0° C. for 30 min and warmed to room temperature for 24 h. Concentration in vacuo gave a residue which was diluted with diethyl ether (200 mL) and washed with water, saturated sodium bicarbonate and brine. The organic layer was separated, dried with sodium sulfate, filtered and concentrated in vacuo giving a white solid 1.62 g (85%), which was used without further purification.

Fuente