Reacción #78803

Ecuación de reacción

DMF

o-aminothiophenol

Ac2O

→

compound ( A )

Rendimiento 32.0%

indole

Rendimiento 32.0%

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONThe reaction mixture was poured
2. 2
   Filtraciónthe precipitated solid was collected by filtration
3. 3
   LavadoThe crude solid was washed with MeOH
4. 4
   Otrorecrystallized from benzene

Procedimiento

A dry DMF solution of the compound (A-2) (0.01 mole) was added o-aminothiophenol (0.013 mole) and Ac2O (0.5ml) at room temperature. The mixture was stirred at 60° C. for 3 h. The reaction mixture was poured into stirred benzene and the precipitated solid was collected by filtration. The crude solid was washed with MeOH and recrystallized from benzene to afford target compound (A) (32% yield). 1H-NMR spectrum is shown in FIG. 3. Photoluminescence spectrum is shown in FIG. 4.

Fuente