Reacción #78732

Ecuación de reacción

CH2Cl2

N-{[(2-{4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethyl)amino]carbonyl}-4-methylbenzenesulfonamide

BrCN

→

title compound

Rendimiento 71.0%

2-AMINO-5,7-DIMETHYL-3-(4-{2-[({[(4-METHYLPHENYL)SULFONYL]AMINO}CARBONYL)AMINO]ETHYL}PHENYL)-3H-IMIDAZO[4,5-b]PYRIDINE DI-HYDROCHLORIDE

Rendimiento 71.0%

Disolventes

THF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with brine
2. 2
   SecadoThe organic layer was dried over MgSO4
3. 3
   Filtraciónfiltered
4. 4
   ConcentraciónAfter concentration in vacuo
5. 5
   Otrothe residue was purified by preparative TLC (CH2Cl2/MeOH=10/1)

Procedimiento

To a stirred solution of N-{[(2-{4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethyl)amino]carbonyl}-4-methylbenzenesulfonamide (300 mg, 0.66 mmol) in THF (6 ml) was added a solution of BrCN (175 mg, 1.65 mmol) in water (2 ml). The resultant mixture was stirred at room temperature for 16 hours. The mixture was diluted with CH2Cl2 and washed with brine. The organic layer was dried over MgSO4 and filtered. After concentration in vacuo, the residue was purified by preparative TLC (CH2Cl2/MeOH=10/1) to afford 224 mg (71%) of the title compound.

Fuente