Reacción #786

Ecuación de reacción

N#Cc1cnn2c(NC3CC3)cc

CC(=O)Nc1cc(N)ccc1C

→

CC(=O)Nc1cc(Nc2cc(NC

Disolventes

CC(=O)N(C)C

Condiciones de reacción

Procedimiento

In a 25 mL round-bottomed flask (t=g) was 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (40 mg, 0.17 mmol), Pd2(dba)3 (7.84 mg, 8.56 µmol), and [Reactants] in DMA (1.5 mL) ([VOLUME]) to give a black suspension.[Reactants] and N-(5-amino-2-methylphenyl)acetamide (28.1 mg, 0.17 mmol) were added. stirred at 110C for 2 days. TLC showed major is SM, small amount of product was formed/ did not workup LCMS showed 349 mass ??

Fuente