Reacción #78217

Ecuación de reacción

methyl 3-bromobenzoate

phenylboronic acid

sodium carbonate

toluene

→

title compound

Methyl 3-phenylbenzoate

Disolventes

—

solvent

water

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered through Celite
2. 2
   workup.ADDITIONafter-treated by an ordinary method
3. 3
   Otropurified by the silica gel column chromatography

Procedimiento

1.00 g (4.65 mmol) of methyl 3-bromobenzoate, 0.60 g (4.88 mmol) of phenylboronic acid, 161 mg (3 molar %) of tetrakistriphenylphosphine palladium and 2.0 g (18.6 mmol) of sodium carbonate were heated under reflux in 24 ml of a solvent mixture of toluene, ethanol and water (2/1/1) for 2 hours. The mixture was filtered through Celite, then after-treated by an ordinary method and purified by the silica gel column chromatography to obtain the title compound.

Fuente