Reacción #78207

Ecuación de reacción

cyanogen bromide

methyl 3,4-diaminobenzoate

→

title compound

Methyl 2-aminobenzimidazole-5-carboxylate

Disolventes

acetonitrile

water

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered
2. 2
   workup.ADDITIONAqueous ammonia was added to the filtrate

Procedimiento

300 mg (1.8 mmol) of methyl 3,4-diaminobenzoate was stirred in 5 ml of water. 0.5 ml of a solution of 5 M of cyanogen bromide in acetonitrile was added to the obtained mixture, and they were stirred at room temperature for 20 minutes. The mixture was filtered. Aqueous ammonia was added to the filtrate. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the title compound was obtained.

Fuente