Reacción #782

Ecuación de reacción

N#Cc1cnn2c(NC3CC3)cc

CC(=O)Nc1cc(N)ccc1N(

→

CC(=O)Nc1cc(Nc2cc(NC

Rendimiento 29.4%

Disolventes

CC(=O)N(C)C

Condiciones de reacción

Procedimiento

In a 40mL vial (t=g) was 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (80 mg, 0.34 mmol), [Reactants], and cesium carbonate (145 mg, 0.45 mmol) in DMA (0.5 mL) ([VOLUME]),Pd2(dba)3 (15.68 mg, 0.02 mmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (19.81 mg, 0.03 mmol) were added. to give a brown suspension. The vial was filled with N2, 150C microwave for 30 min. LCMS showed completion. concentrated. loaded on ISCO (Hex to Hex:EtOAc To EtOAc:MeOH=10:1 to EtOAc:MeOH:Et3N=10:1:0.1) to give yellow solid. This yellow solid was washed with EtOAc(1mL) and Et2O(2mL) to give 50 mg pure compound. NMR, 1H,HPLC are OK, see attachment

Fuente