Reacción #78078

Ecuación de reacción

water

5-bromo-2,4-dichloropyrimidine

4-methoxyphenol

potassium carbonate

→

product

Rendimiento 96.0%

5-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine

Rendimiento 96.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solid which separated out
2. 2
   Filtraciónwas collected by filtration
3. 3
   Lavadowashed with water (50 ml)
4. 4
   Otrodried under high vacuum

Procedimiento

A mixture of 5-bromo-2,4-dichloropyrimidine (5.0 g, 22.0 mmol), 4-methoxyphenol (2.72 g, 22.0 mmol) and potassium carbonate (6.07 g, 44.0 mmol) in DMF (20 ml) was stirred for 24 hours. The mixture was added to water (100 ml) and the solid which separated out was collected by filtration, washed with water (50 ml) and dried under high vacuum to give the product (6.6 g, 96%). NMR: 3.8 (s, 3H), 7.0 (d, 2H), 7.2 (d, 2H), 8.8 (s, 11H).

Fuente